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Pothos are native to the French Polynesian forests, where they are understory vines that receive bright, indirect sunlight. As a highly variegated indoor plant, Harlequin needs the brightest indirect light you can give without exposing it to direct sunlight.
Your Harlequin will not appreciate either cold or hot drafts and may droop and drop leaves. Keep it out of the way of a hot air or air conditioner vent, and move it away from a cold, drafty window in the winter.
Harlequin pothos will adapt to low humidity in a household, which is usually in the 30 to 40 percent range, but because of its tropical heritage, it prefers 40 to 60 percent humidity.